**Product Name:** 1H-Indazole-3-carboxylic Acid
**CAS Number:** 4498-67-3
**Molecular Formula:** C₈H₆N₂O₂
**Molecular Weight:** 162.15 g/mol
**Purity (HPLC):** ≥ 98.0% [*Placeholder – Certificate of Analysis available upon request*]
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## Product Overview
1H-Indazole-3-carboxylic acid is a key heterocyclic building block widely employed in medicinal chemistry and pharmaceutical research. The indazole core is a privileged scaffold found in numerous clinically approved drugs targeting kinase inhibition, anti-inflammatory pathways, and oncology applications.
## Applications in Research
– **Kinase Inhibitor Synthesis:** Serves as a critical intermediate in the preparation of selective kinase inhibitors, particularly those targeting FGFR, VEGFR, and SRC-family kinases.
– **GPCR Ligand Development:** The carboxylic acid moiety enables facile amide coupling for the synthesis of G-protein coupled receptor (GPCR) modulators.
– **Lead Optimization:** The 3-position carboxylic acid allows for diverse derivatization, making it an ideal starting point for structure-activity relationship (SAR) studies.
## Analytical Data
| Parameter | Specification |
|———–|—————|
| Appearance | Off-white to pale yellow crystalline powder |
| Purity (HPLC) | ≥ 98.0% (COA available) |
| Melting Point | 265–268 °C (dec.) |
| Solubility | Soluble in DMSO, DMF; partially soluble in MeOH, EtOH |
| Storage | Store at 2–8 °C, protected from moisture |
| Shipping | FOB Shanghai, vacuum-sealed packaging |
## Pricing
| Package Size | Price (USD) |
|————-|————-|
| 1 g | $300 |
| 5 g | $1,200 |
| 25 g | Inquire for bulk pricing |
All prices are quoted FOB Shanghai. Larger quantities available upon request.
## Custom Synthesis
We offer custom synthesis services for indazole derivatives with varying substitution patterns. Please contact us for quotations on non-catalog items.
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