**Product Name:** 5-Bromo-1H-indazole-3-carboxylic Acid
**CAS Number:** 1077-94-7
**Molecular Formula:** C₈H₅BrN₂O₂
**Molecular Weight:** 241.04 g/mol
**Purity (HPLC):** ≥ 97.0% [*Placeholder – Certificate of Analysis available upon request*]
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## Product Overview
5-Bromo-1H-indazole-3-carboxylic acid is a halogen-functionalized indazole derivative that serves as a versatile intermediate in pharmaceutical research. The bromine substituent at the 5-position enables further cross-coupling reactions (Suzuki, Buchwald-Hartwig, Sonogashira) for rapid scaffold diversification.
## Applications in Research
– **Cross-Coupling Chemistry:** The aryl bromide handle facilitates palladium-catalyzed coupling reactions, enabling rapid access to diversely substituted indazole libraries.
– **Fragment-Based Drug Discovery (FBDD):** Used as a starting fragment for the construction of focused libraries targeting bromodomain-containing proteins and kinase targets.
– **Bioisosteric Replacement:** The indazole-3-carboxylic acid moiety serves as a bioisostere for amide and ester functionalities in lead optimization campaigns.
## Analytical Data
| Parameter | Specification |
|———–|—————|
| Appearance | Light brown to tan crystalline powder |
| Purity (HPLC) | ≥ 97.0% (COA available) |
| Melting Point | 278–282 °C (dec.) |
| Solubility | Soluble in DMSO, DMF |
| Storage | Store at 2–8 °C, protected from light and moisture |
| Shipping | FOB Shanghai, vacuum-sealed packaging |
## Pricing
| Package Size | Price (USD) |
|————-|————-|
| 1 g | $800 |
| 5 g | $3,200 |
| 25 g | Inquire for bulk pricing |
All prices are quoted FOB Shanghai. Smaller gram quantities available for preliminary screening.
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